Case study. Interaction of the AEDL peptide with DNA

25.12.2019, 05:11

In the cell culture experiments, the AEDL peptide proved to be an efficient agent stimulating the cell renewal processes and the enhancement of the functional activity of bronchial epithelial cells. A presumed target of the peptide action is a DNA molecule.

The work studies the peptide binding with high-molecular DNA in solutions with different ionic strengths.

The spectral (UV spectophotometery and circular dichroism) and hydrodynamic (viscosimetry) methods show that, under the experimental conditions, the AEDL peptide forms a complex with DNA and that nitrogen bases are involved in the binding.

The character of spectral changes in DNA suggests a possible interaction of the AEDL peptide with DNA in the major furrow at the guanine N7 site without a visible distortion of the double helix structure.

Other news
14.03.2023
Peptides are very important molecules because they perform key functions in biological processes. Their unique characteristics have been studied for several years as promising for...
14.03.2023
About 40 years ago, Professor Vladimir Khavinson, now Director of the Saint Petersburg Institute of Bioregulation and Gerontology, initiated research on bioregulatory peptides. His clinical...
14.03.2023
Endocrine glands are glands of epithelial origin that secrete hormones directly into the bloodstream so that they can reach organs and tissues. The pineal gland...
18.02.2023
Supplements are food product intended to supplement the common diet and constitute a concentrated source of nutrients, such as vitamins and minerals, or other substances...