Case study. Interaction of the AEDL peptide with DNA
25.12.2019, 05:11
In the cell culture experiments, the AEDL peptide proved to be an efficient agent stimulating the cell renewal processes and the enhancement of the functional activity of bronchial epithelial cells. A presumed target of the peptide action is a DNA molecule.
The work studies the peptide binding with high-molecular DNA in solutions with different ionic strengths.
The spectral (UV spectophotometery and circular dichroism) and hydrodynamic (viscosimetry) methods show that, under the experimental conditions, the AEDL peptide forms a complex with DNA and that nitrogen bases are involved in the binding.
The character of spectral changes in DNA suggests a possible interaction of the AEDL peptide with DNA in the major furrow at the guanine N7 site without a visible distortion of the double helix structure.
Other news
22.01.2020
The search for new safe and efficient low molecular weight substances stimulating skin regeneration is an important objective of cosmetology.
22.01.2020
The term “Peptide” is actually common in the world of biochemistry and is the generic name given to a small string of amino acids. Amino acids are the so called building blocks of life.
14.11.2019
EPITALON® Spray – new generation of food supplements. Its complex of amino acids re-aligns internal body clock with the day-night cycle by physiological induction of synthesis of natural melatonin.
© 2018-2020 Company Nanopep INC Limited