Case study. Interaction of the AEDL peptide with DNA
25.12.2019, 05:11
In the cell culture experiments, the AEDL peptide proved to be an efficient agent stimulating the cell renewal processes and the enhancement of the functional activity of bronchial epithelial cells. A presumed target of the peptide action is a DNA molecule.
The work studies the peptide binding with high-molecular DNA in solutions with different ionic strengths.
The spectral (UV spectophotometery and circular dichroism) and hydrodynamic (viscosimetry) methods show that, under the experimental conditions, the AEDL peptide forms a complex with DNA and that nitrogen bases are involved in the binding.
The character of spectral changes in DNA suggests a possible interaction of the AEDL peptide with DNA in the major furrow at the guanine N7 site without a visible distortion of the double helix structure.
Other news
31.08.2023
The popularity of dietary supplements continues to grow. According to a survey by Food Supplements Europe, around 90 % of more than 13,000 respondents said...
31.08.2023
Science and scientific know-how are key to the long-term enhancement of human life and health. Research is a fundamental driver of innovation, and the study...
31.08.2023
The proper functioning of the body depends on the functional interaction between different types of molecules from the same or different groups. One such group...
31.08.2023
Do you know why we create CRONOREX®spray? No? We developed CRONOREX® because we care about people health. It is not by chance that our declared...
Keep in Touch
ADDRESS:
Via Adige, 1 64028 Silvi, Italy
Working hours from 09.00 to 17.00 (Monday to Friday)
© 2018-2023 Company Nanopep INC Limited